A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
Identifieur interne : 003419 ( Main/Exploration ); précédent : 003418; suivant : 003420A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
Auteurs : M.-C. Carrillo [Argentine, Japon] ; S. Kanai [Japon] ; K. Kitani [Japon] ; G. O. Ivy [Japon, Canada]Source :
- Life Sciences [ 0024-3205 ] ; 2000.
Abstract
The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.
Url:
DOI: 10.1016/S0024-3205(00)00838-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002126
- to stream Istex, to step Curation: 002126
- to stream Istex, to step Checkpoint: 001140
- to stream Main, to step Merge: 003947
- to stream Main, to step Curation: 003419
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><author><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name></author><author><name sortKey="Kanai, S" sort="Kanai, S" uniqKey="Kanai S" first="S." last="Kanai">S. Kanai</name></author><author><name sortKey="Kitani, K" sort="Kitani, K" uniqKey="Kitani K" first="K." last="Kitani">K. Kitani</name></author><author><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A0BF68DE380D904402B1EAD0EA8B98548DF4A267</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0024-3205(00)00838-9</idno><idno type="url">https://api-v5.istex.fr/document/A0BF68DE380D904402B1EAD0EA8B98548DF4A267/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002126</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002126</idno><idno type="wicri:Area/Istex/Curation">002126</idno><idno type="wicri:Area/Istex/Checkpoint">001140</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001140</idno><idno type="wicri:doubleKey">0024-3205:2000:Carrillo M:a:high:dose</idno><idno type="wicri:Area/Main/Merge">003947</idno><idno type="wicri:Area/Main/Curation">003419</idno><idno type="wicri:Area/Main/Exploration">003419</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats</title><author><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name><affiliation wicri:level="1"><country xml:lang="fr">Argentine</country><wicri:regionArea>Institute De Fisiologia, Experimental, Suipacha 570, 2000Rosario, Universidad Nacional De Rosario</wicri:regionArea><wicri:noRegion>Universidad Nacional De Rosario</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kanai, S" sort="Kanai, S" uniqKey="Kanai S" first="S." last="Kanai">S. Kanai</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kitani, K" sort="Kitani, K" uniqKey="Kitani K" first="K." last="Kitani">K. Kitani</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>National Institute for Longevity Sciences, 36-3, Gengo, Moriokacho, Obu, Aichi, 4748522</wicri:regionArea><wicri:noRegion>4748522</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Metropolitan Institute of Gerontology, 35-2, Sakaecho, Itabashiku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation><affiliation wicri:level="4"><country>Canada</country><wicri:regionArea>Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">67</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="2539">2539</biblScope><biblScope unit="page" to="2548">2548</biblScope></imprint><idno type="ISSN">0024-3205</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The survival rate of male Fischer-344/Du rats treated chronically with high doses of deprenyl was investigated. Eighteen month old rats were treated with 1 mg/kg s.c. deprenyl 3 times per week for 13 months. At the age of 31 months, treated rats showed a greater mortality rate with three of 12 rats surviving, while in saline-treated control animals seven of 12 animals survived. No significant differences in superoxide dismutase (SOD) or catalase (CAT) activities in brain regions of control and treated animals were seen at 31 months of age. In contrast, when 27 month old rats were treated in the same manner for one month, significant increases in SOD (both Cu,Zn- and Mn-) and CAT activities were found in substantia nigra, striatum and cerebral cortex, but not in hippocampus. This effect was produced with a wide range of deprenyl doses (0.25–2 mg/kg, but not 4 mg/kg). Although a causal relationship between the two different effects of the drug, i.e. 1) increases in antioxidant enzyme activities and 2) the prolongation of survival of animals, has not been directly demonstrated, the loss of both effects with the high dose of the drug in the present experiment may be taken as circumstantial evidence for their causal relationship.</div></front></TEI><affiliations><list><country><li>Argentine</li><li>Canada</li><li>Japon</li></country><region><li>Ontario</li></region><settlement><li>Tokyo</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Argentine"><noRegion><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Carrillo, M C" sort="Carrillo, M C" uniqKey="Carrillo M" first="M.-C." last="Carrillo">M.-C. Carrillo</name></noRegion><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name><name sortKey="Kanai, S" sort="Kanai, S" uniqKey="Kanai S" first="S." last="Kanai">S. Kanai</name><name sortKey="Kitani, K" sort="Kitani, K" uniqKey="Kitani K" first="K." last="Kitani">K. Kitani</name></country><country name="Canada"><region name="Ontario"><name sortKey="Ivy, G O" sort="Ivy, G O" uniqKey="Ivy G" first="G. O." last="Ivy">G. O. Ivy</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003419 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003419 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A0BF68DE380D904402B1EAD0EA8B98548DF4A267
|texte= A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
}}
| This area was generated with Dilib version V0.6.29. |  |